Hippo Signaling Goes Long Range
نویسندگان
چکیده
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
منابع مشابه
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عنوان ژورنال:
- Cell
دوره 150 شماره
صفحات -
تاریخ انتشار 2012